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Woman of child bearing potential, and men with female partners of child bearing potential, must agree to use adequate contraceptive measures (see section 7.1.11.1) for the duration of the study and for up to 6 months after the completion of study treatment.

Postmenopausal women must have been amenorrhoeic for at least 12 months to be considered of non-childbearing potential

Negative serum Human Chorionic Gonadotropin (HCG) test for females with child bearing potential.

Estimated creatinine clearance ≥ 60 mL/min (as calculated by Cockcroft and Gault or Wright formula or measured by EDTA clearance).

Aspartate transaminase (AST) and alanine aminotransferase (ALT) ≤ 2.5 x ULN (or <5 x ULN in the presence of liver metastases).

Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) unless bilirubin rise is due to Gilbert's syndrome.

Eastern Cooperative Oncology Group performance status 0 and 1Īdequate liver/bone marrow function as defined by:.

Able to undergo biliary drainage using a covered or partially covered self-expanding metal stent if jaundiced.

Histological or cytologically proven pancreatic ductal adenocarcinoma (including variants).

Resectable or borderline resectable pancreatic cancer as defined by National Comprehensive Cancer Network criteria following discussion at the Multi Disciplinary Team.

Signed informed consent given for PRIMUS 002 study.

Patient has been enrolled in the Precision-Panc Master Protocol and their tissue has been deemed suitable for Next Generation Sequencing analysis (a Precision-Panc Master Protocol identifier will be required at the time of study enrolment).

Why Should I Register and Submit Results?.

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